|Tetsuro Sakai, MD, PhD
||Yan Xu, PhD
The paper “Stem Cells Decreased Neuronal Cell Death After Hypoxic Stress in Primary Fetal Rat Neurons in Vitro” by Tetsuro Sakai, MD, PhD and Yan Xu, PhD was recently published in Cell Transplantation (2012;21(1):355-64. Epub 2011 Jun 7. IF 6.204).
The paper describes research in which Sakai and Xu explored the role of stem cells in providing neuroprotection after ischemic brain injury using rat umbilical cord matrix (RUCM)-derived stem cells in an in vitro co-culture system. They found that direct co-culturing of RUCM-derived stem cells with primary rat fetal hippocampal neuronal cells after 96 h of hypoxia decreased neuronal cell apoptosis and neuronal cell death, suggesting that stem cells may offer neuronal protection through extracellular signaling.