University of PttsburghDepartment of Anesthesiology
 
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Publications

 

Dallasen RM, Bowman JD, Xu Y.  Isoflurane Does Not Cause Neuroapoptosis But Reduces Astroglial Processes  in Young Adult Mice, Medical Gas Research, 1:27, Published online November 3, 2011. doi:10.1186/2045-9912-1-27  (2011)

Willenbring, D, Liu, LT, Mowrey, D, Xu, Y, Tang, P, Isoflurane Alters the Structure and Dynamics of GLIC, Biophysical J, 101, 1905-1912, (2011) PMCID PMC3192980
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Xiong Wei, Cheng KJ, Cui T, Godlewski G, Rice KC, Xu Y, Zhang L.  Cannabinoid Potentiation of Glycine Receptors Contributes to Cannabis-Induced Analgesia, Nat Chem Biol, Published online April 3, 2011. (2011) PMCID Journal in Process
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Wang HJ, Kleinhammes A, Tang P, Xu Y, Wu Y.  Temperature Dependence of Lysozyme Hydration and the Role of Elastic Energy, Phys Rev E, 83(031924).(2011) PMCID Journal In Process
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Chen Q, Cheng, HM, Xu, Y, Tang P, Anesthetic Binding in a Pentameric Ligand-gated Ion Channel: GLIC, Biophysical J, 99: 1801-1809, (2010) PMCID:  PMC2941008
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Willenbring D, Xu Y, Tang P, The Role of Structured Water in Mediating General Anesthetic Action on alpha4beta2 nAChR, Phys Chem Chem Phys, 12: 10263 -10269 (2010) NIHMS246160
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Liu LT, Xu Y, Tang P, Mechanistic Insights into Xenon Inhibition of NMDA Receptors from MD Simulations, J Phys Chem B, 114: 9010-9016 (2010) PMCID: PMC2903204
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Mowrey D, Haddadian EJ, Liu LT, Willenbring D, Xu Y, Tang P, Unresponsive Correlated Motion in alpha7 nAChR to Halothane Binding Explains Its Functional Insensitivity to Volatile Anesthetics, J Phys Chem B, 114: 7649-7655 (2010) PMCID: PMC2888140
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Bondarenko V, Tillman T, Xu Y, Tang P, NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit, Biochim Biophys Acta Biomembranes, 1798: 1608-1614 (2010) PMCID: PMC2885491
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Liu LT, Haddadian EJ, Willenbring D, Xu Y, Tang P, Higher Susceptibility to Halothane Modulation in Open- Than in Closed-channel alpha4beta2 nAChR Revealed by Molecular Dynamics Simulations, J Phys Chem B, 114: 626-632 (2010) PMCID: PMC2805416
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Cui T, Canlas C, Xu Y, Tang P, Anesthetic Effects on the Structure and Dynamics of the Second Transmembrane Domains of nAChR alpha4beta2, BBA - Biomembranes, 1798,161-166 (2010) PMCID: PMC2812609
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Liu LT, Willenbring D, Xu Y, Tang P, General Anesthetic Binding to a42 nAChR and Its Effects on Global Dynamics, J Phys Chem B, 113:12581-12589 (2009) PMCID: PMC2749472
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Cheng, MH, Xu, Y, Tang P, Anionic Lipid and Cholesterol Interactions with a42 nAChR: Insights from MD Simulations, J Phys Chem B, 113, 6964-70 (2009) PMCID: PMC2698126
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Kubo K, Nakao S, Jomura S, Sakamoto S, Miyamoto E, Xu Y, Tomimoto H, Inada T, Shingu K: Edaravone, A Free Radical Scavenger, Mitigates Both Gray and White Matter Damages after Global Cerebral Ischemia in Rats, Brain Res, 1279:139-46 (2009)
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Xu Y, Liachenko SM, Tang P, Chan PH: Faster Recovery of Cerebral Perfusion in SOD1-Overexpressed Rats after Cardiac Arrest and Resuscitation, Stroke, 40(7): 2512-8 (2009) PMCID: PMC2919566
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Hirko A, Dallasen R, Jomura S,  Xu Y: Modulation of Inflammatory Responses after Global Ischemia by Transplanted Umbilical-Cord Matrix Stem Cells, Stem Cells, 26:2893-2901 (2008) PMCID: PMC2802492
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Haddadian E, Cheng M, Coalson R, Xu Y, Tang P: In Silico models for the Human a4b2 Nicotinic Acetylcholine Receptor, J Phys Chem B, 112, 13981-90 (2008) PMCID: PMC2775927
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Ma D, Tillman T, Tang P, Meirovitch E, Eckenhoff R, Carnini A, Xu Y: NMR Studies of a Channel Protein Without Membranes:  Structure and Dynamics of Water-Solubilized KcsA, Proc. Natl Acad Sci USA, 105:16537-16542 (2008 )PMCID: PMC2572164
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Canlas C, Cui T, Li L, Xu Y, Tang P: Anesthetic Modulation of Protein Dynamics: Insight From an NMR Study, J Phys Chem B, 112: 14312-14318 (2008) PMCID: PMC2669902
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Canlas C, Ma D, Li L, Tang P, Xu Y: Residual Dipolar Coupling Measurements of Transmembrane Proteins Using Aligned Low-q Bicelles and High-resolution Magic Angle Spinning NMR Spectroscopy, J Am Chem Soc, 130: 13294-13300 (2008) PMCID: PMC2704097
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Bondarenko V, Yushmanov VE, Xu Y, Tang P: NMR Study of General Anesthetic Interaction with nAChR â2 Subunit, Biophysical J, 94, 1681-1688, (2008) PMCID: PMC2242774
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Cui T, Bondarenko V, Ma D, Canlas CG, Brandon NR, Johansson JS, Xu Y, Tang P: Four-á-Helix Bundle with Designed Anesthetic Binding Pockets II: Halothane Effects on Structure and Dynamics, Biophysical J, 94: 4464-72, (2008) PMCID:  PMC2480694
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Ma D, Brandon NR, Cui T, Bondarenko V, Canlas CG, Johansson JS, Tang P, Xu Y: Four-á-Helix Bundle with Designed Anesthetic Binding Pockets I: Structural and Dynamical Analyses, Biophysical J, 94: 4454-63, (2008) PMCID: PMC2480675
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Cheng MH, Liu LT, Saladino A, Xu Y, Tang P: Molecular Dynamics Simulations of Ternary Membrane Mixture - Phosphatidylcholine, Phosphatidic Acid, and Cholesterol, J Phys Chem B, 111, 14186-92, (2007)
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Szarecka A., Xu Y., Tang P. "Dynamics of heteropentameric nicotinic acetylcholine receptor: Implications of the gating mechanism." Proteins 68(4): 948-960. (2007)
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Szarecka A., Xu Y., Tang P. "Dynamics of Firefly Luciferase Inhibition by General Anesthetics: Gaussian and Anisotropic Network Analyses." Biophys J. ASAP (2007)
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Jomura S, Uy M, Mitchell K, Dallasen R, Bode C, Xu Y: Potential Treatment of Cerebral Global Ischemia with Umbilical Cord Matrix Stem Cells, Stem Cells, 25:98-106 (2007).
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Yushmanov V, Mandal PK, Liu ZW, Tang P, Xu Y: NMR Structure and Backbone Dynamics of the Extended Second Transmembrane Domain of the Human Neuronal Glycine Receptor Alpha-1 Subunit, Biochemistry, 42, 3989-3995 (2003).
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Liachenko S, Tang P, Xu Y: Deferoxamine Improves Early Postresuscitation Reperfusion and Neurological Recovery after Prolonged Cardiac Arrest in Rats, J Cereb Blood Flow & Metab, 23,574-581 (2003)
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Tang P, Xu Y: Large-Scale Molecular Dynamics Simulations of General Anesthetic Effects on Ion Channel in Fully Hydrated Membrane: Implication of Molecular Mechanisms of General Anesthesia, Proc Natl Acad Sci USA, 99: 16035-16040 (2002)
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Tang P, Mandal PK, Xu Y: Structures of Second Transmembrane Domain of Human Glycine Receptor a1 Subunit: Pore Architecture and Possible Channel Gating Mechanism, Biophys J, 83: 252-262 (2002)
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Wang L, Yushmanov VE, Liachenko SM, Tang P, Hamilton RL, Xu Y: Late Reversal of Cerebral Perfusion and Water Diffusion after Transient Focal Ischemia in Rats, J Cereb Blood Flow & Metab, 22: 253-261 (2002)
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Xu Y, Liachenko SM, Tang P: Dependence of Early Cerebral Reperfusion and Long-Term Outcome on Resuscitation Efficiency Following Cardiac Arrest in Rats, Stroke, 33: 837-843 (2002)
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Yushmanov V, Wang L, Liachenko S, Tang P, Xu Y: ADC Characterization of Region-Specific Response to Cerebral Perfusion Deficit in Rats by MRI at 9.4 T, Magn Reson Med, 47: 562-570 (2002)
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Liachenko S, Tang P, Hamilton RL, Xu Y: Regional Dependence of Cerebral Reperfusion after Circulatory Arrest in Rats, J Cereb Blood Flow & Metab, 21: 1320-1329 (2001) 
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Tang P, Zubrzycki IZ, Xu Y: Ab Initio Calculation of Structures and Properties of Halogenated General Anesthetics: Halothane and Sevoflurane, J Comput Chem, 4: 436-444 (2001)
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Zubrzycki IZ, Xu Y, Madrid M, Tang P: Molecular Dynamics Simulations of a Fully Hydrated Dimyristoylphosphatidylcholine Bilayer in Liquid-Crystalline Phase, J Chem Phys, 112:3437-3441 (2000) 
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Tang P, Eckenhoff RG, Xu Y: General Anesthetic Binding to Gramicidin A: The Structural Requirement, Biophysical J, 78:1804-1809 (2000)
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Xu Y, Seto T, Tang P, Firestone L: NMR study of volatile anesthetic binding to nicotinic acetylcholine receptors, Biophysical J, 78:746-751 (2000)
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Tang P, Hu J, Liachenko S, Xu Y: Distinctly different interactions of anesthetic and nonimmobilizer with transmembrane channel peptide, Biophysical J, 77:739-746 (1999)
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Tang P, Simplaceaue V, Xu Y: Structural consequences of anesthetic and nonimmobilizer interaction with transmembrane channel peptide, Biophysical J, 76:2346-2350 (1999)
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Liachenko S, Tang P, Somogyi GS, Xu Y: Concentration-dependent isoflurane effects on depolarization-evoked glutamate and GABA outflow from mouse brain slices, British J Pharmacology, 127:131-138 (1999)
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Xu Y, Tang P, and Liachenko S: Unifying characteristics of sites of anesthetic action revealed by combined use of anesthetics and nonanesthetics, Toxicology Letters, 100:347-352 (1998)
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Liachenko S, Tang P, Hamilton RL, and Xu Y: A highly reproducible model of circulatory arrest and remotely controlled resuscitation in rats, Stroke, 29, 1229-1238 (1998).
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Tang P, Liachenko S, and Xu Y: 31P/1H NMR study of mitigating effects of GYKI 52466 on kainate-induced metabolic impairment in perfused rat cerebrocortical slices, Epilepsia, 39, 577-583 (1998)
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Liachenko S, Tang P, Somogyi G, and Xu Y: Comparison of anaesthetic and non-anaesthetic effects on depolarisation-evoked glutamate and GABA release from mouse cerebrocortical slices, British J Pharmacology, 123, 1274-1280 (1998).
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Tang P, Yan B, Xu Y: Different distribution of fluorinated anesthetics and nonanesthetics in phosphatidylcholine lipid vesicles: A 19F NMR investigation, Biophysical Journal 72, 1676-1682 (1997).
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Xu Y and Tang P: Easy fabrication of a tunable high-pass birdcage resonator, Magn Reson Med 37, 168-172, (1997).
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Xu Y and Tang P: Amphiphilic sites for general anesthetic action? Evidence from 129Xe-{1H} intermolecular nuclear Overhauser effects, Biochim Biophys Acta 1323, 154-162 (1997).
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Bedu-Addo FK, Tang P, Xu Y, and Huang L: Effects of polyethyleneglycol chain length and phospholipid acyl chain composition on the interaction of polyethyleneglycol-phospholipid conjugates with phospholipid: Implications in liposomal drug delivery, Pharmaceutical Research 13, 710-717 (1996).
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Bedu-Addo FK, Tang P, Xu Y, and Huang L: Interaction of polyethyleneglycol-phospholipid conjugates with cholesterol-phosphatidylcholine mixtures: Sterically stabilized liposome formulations, Pharmaceutical Research 13, 718-724 (1996).
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Xu Y, Tang P, Firestone L, and Zhang TT: 19F-NMR investigation of stereoselective binding of isoflurane to bovine serum albumin, Biophysical Journal 70, 532-538 (1996).
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Xu Y, Tang P, Zhang W, Firestone L, and Winter PM: Fluorine-19 NMR imaging and spectroscopy of sevoflurane uptake, distribution, and elimination in rat brain, Anesthesiology 83, 766-774 (1995).
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Hyde EG, Boyer A, Tang P, Xu Y, and Abramson SN: Irreversible inhibitors of nicotinic acetylcholine receptors: Isolation and structural characterization of the biologically active solvolysis products of bipinnatin-A and bipinnatin-C, J Med Chem 38, 2231-2238 (1995).
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Espanol MT, Litt L, Xu Y, Chang L-H, James TL, Weinstein PR, and Chan PH. 19F NMR calcium changes, edema, and histology in neonatal rat brain slice during glutamate toxicity. Brain Research 647, 172-176 (1994).
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Espanol MT, Xu Y, Litt L, Chang L-H, James TL, Weinstein PR, and Chan PH. Modulation by dizocilpine, kynurenate, and NBQX of edema in respiring brain slices after glutamate toxicity. Acta Neurochirurgica 60, 58-61 (1994).
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Espanol MT, Xu Y, Litt L, Yang GL, Chang L-H, James TL, Weinstein P, and Chan PH. Modulation of glutamate-induced intracellular energy failure in cerebral cortical slices by kynurenic acid, dizocilpine, and NBQX. J Cereb Blood Flow Metab 14, 269-278 (1994).
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Litt L, Xu Y, Cohen Y, Severinghaus JW, and James TL. A nonmagnetic hyperbaric chamber for in vivo MR studies of small animals. Magn Reson Med 29, 812-816 (1993).
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