Go to Site Home Page Go to University of Pittsburgh Home Page Go to UPMC Home Page
Anesthesiology
NEWS
In Collaboration with Several Carnegie Mellon University Faculty, Dr Quinlan is Published in PNAS

The Effect of Midazolam on Visual Search: Implications for Understanding Amnesia
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17879-83. Epub 2004 Dec 13

"The notion of multiple memory systems based on conscious accessibility has been supported largely by neuropsychological patient studies. Specifically, it was widely held that amnesic patients have impaired explicit memory performance but spared implicit memory performance. However, recent patient studies have called the implicit/explicit memory distinction into question. In this study, normal participants were tested on a visual search task, once after an injection of midazolam, an anesthetic that induces temporary amnesia, and once after an injection of saline. Under the influence of midazolam, participants did not show facilitation in search times for repeated configurations (contextual cuing), although there was a general speed-up in performance across blocks in both the midazolam and saline conditions. Neither the contextual-cuing effect nor the procedural-learning effect was available to subjective experience, yet only one of these was affected by midazolam-induced amnesia. These data call into question the notion that memory systems divide on the basis of subjective experience of consciousness or reportability. Rather, the findings support the contention that anterograde amnesia affects learning that depends on building novel associations in memory and that this deficit does not hinge upon accessibility to consciousness." [more]


Williams | 23-Dec-2004 | bws
2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
2013
December 2013
November 2013
October 2013
September 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
2012
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
2011
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
2010
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
March 2009
February 2009
January 2009
2008
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
May 2008
April 2008
March 2008
February 2008
January 2008
November 2007
2003
October 2003
September 2003
August 2003
July 2003
June 2003
May 2003
April 2003